5-Hydroxytryptamine4 receptor agonists and colonic motility.
نویسنده
چکیده
5-Hydroxytryptamine (5-HT) released from enterochromaffin cells regulates gastrointestinal function in either an excitatory or inhibitory manner. 5-HT(3) and 5-HT(4) receptors in the gut have been the focus of clinical studies on the management of gastrointestinal motility disorders. 5-HT stimulates intestinal propulsive reflexes through 5-HT(4) receptors. 5-HT(4) receptor agonists can stimulate upper or lower gut motility, depending on their selectivity and affinity. In the guinea pig colon, the distribution of 5-HT(4) receptors in the myenteric plexus and circular muscle layer differs between the proximal and distal regions. 5-HT stimulates intestinal motility via excitatory neurons while causing relaxation of the circular muscle via 5-HT(4) receptors. In the light of these findings on the distribution of 5-HT(4) receptors, the effects of receptor agonist compounds could vary depending on the species of experimental animal and the anatomical region studied.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
دوره 45 1 شماره
صفحات -
تاریخ انتشار 2009